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Intermittent and periodic fasting, longevity and disease

by Ageing and Longevity | Mar 6, 2021 | Uncategorized

We have all heard of the benefits of intermittent fasting and longevity. In this review, Longo and colleagues discuss the latest cellular and organismal literature involving intermittent and periodic fasting, and their effect on ageing. Intermittent fasting is defined... Read More

Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging

by Ageing and Longevity | Mar 6, 2021 | Uncategorized

As most will know, senescent cells lead to a plethora of ageing-related pathophysiologies. In this recent study, Chambers et al. describe how cutaneous senescent fibroblasts are responsible for the non-specific immune response to injection of varicella zoster virus... Read More

The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress

by Ageing and Longevity | Mar 6, 2021 | Uncategorized

In this elegant study, Li and colleagues show how the mitochondrial unfolded protein response (UPRmt) can promote longevity in Caenorhabditis elegans. Using a focused RNAi screen, the authors discover that CREB-binding protein 1 (CBP-1) is a crucial mediator of the... Read More

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age

by Ageing and Longevity | Dec 26, 2020 | Uncategorized

First published on 07 October 2020, this study establishes for the first time that although extracellular vesicle (EV) particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during... Read More
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