Oxford Society
of Ageing and Longevity
We are a student-led organisation with the goal of highlighting cutting-edge ageing research and treatments that target the underlying biology of ageing. By spreading awareness, we hope to inspire the next generation of scientists and biotech entrepreneurs.
A Cure for Ageing?
We treat cancer, visual impairment, heart disease and other ailments individually. The list is vast and extensive. But what if we could treat the root cause of nearly all disease? What if we could cure aging itself?
Seem far fetched?
We know, we know… But it’s a lot more plausible than it sounds. For the first time in human history we’re at a convergent point of CRISPR, Epigenetics, Genome-Wide Association Studies, Artificial Intelligence, Gene Therapy, and a whole slew of other new areas of growth in the coming decade.
Research Highlights
Intermittent and periodic fasting, longevity and disease
We have all heard of the benefits of intermittent fasting and longevity. In this review, Longo and colleagues discuss the latest cellular and organismal literature involving intermittent and periodic fasting, and their effect on ageing. Intermittent fasting is defined...
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
As most will know, senescent cells lead to a plethora of ageing-related pathophysiologies. In this recent study, Chambers et al. describe how cutaneous senescent fibroblasts are responsible for the non-specific immune response to injection of varicella zoster virus...
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress
In this elegant study, Li and colleagues show how the mitochondrial unfolded protein response (UPRmt) can promote longevity in Caenorhabditis elegans. Using a focused RNAi screen, the authors discover that CREB-binding protein 1 (CBP-1) is a crucial mediator of the...
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