We have all heard of the benefits of intermittent fasting and longevity. In this review, Longo and colleagues discuss the latest cellular and organismal literature involving intermittent and periodic fasting, and their effect on ageing. Intermittent fasting is defined...

As most will know, senescent cells lead to a plethora of ageing-related pathophysiologies. In this recent study, Chambers et al. describe how cutaneous senescent fibroblasts are responsible for the non-specific immune response to injection of varicella zoster virus...

In this elegant study, Li and colleagues show how the mitochondrial unfolded protein response (UPRmt) can promote longevity in Caenorhabditis elegans. Using a focused RNAi screen, the authors discover that CREB-binding protein 1 (CBP-1) is a crucial mediator of the...

First published on 07 October 2020, this study establishes for the first time that although extracellular vesicle (EV) particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during...